I usually prioritize tasks that have the biggest impact on achieving my main goals. Helps avoid getting sidetracked by less important stuff that feels urgent in the moment but isn't really moving me forward, ya know?
I find the Eisenhower Matrix super helpful for this - categorizing tasks into urgent/important quadrants. Knock out the urgent and important stuff first, then important but not urgent, and so on. Having that framework to fall back on takes a lot of the stress out of prioritizing for me.